Evidence supporting the use of: L-theanine
For the body system: Dopamine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-theanine is an amino acid primarily found in green tea. Its use to support the dopamine system is grounded in some scientific evidence, though not robust. Preclinical studies in animals and limited human research suggest that L-theanine may influence dopamine levels in the brain. For example, animal studies have shown that L-theanine can increase concentrations of dopamine and serotonin, particularly in the striatum and other brain regions associated with mood and reward. Human studies are less conclusive but indicate that L-theanine may contribute to improved mood, relaxation, and cognitive performance, which are effects sometimes linked to dopamine modulation.

However, the majority of human research on L-theanine focuses on its anxiolytic (anxiety-reducing) effects and its ability to promote relaxation without sedation, often in the context of caffeine co-administration. Direct evidence for L-theanine’s impact on dopamine in humans is limited. Therefore, while there is some scientific basis for using L-theanine to support the dopamine body system, the evidence is not strong or comprehensive. The rating of 2 reflects preliminary, mostly animal-based support, with a need for more robust clinical studies in humans to confirm these effects.

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