Evidence supporting the use of: Rosavins
For the body system: Dopamine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rosavins are a group of compounds found primarily in Rhodiola rosea, an adaptogenic herb traditionally used in Eastern European and Asian medicine. Scientific interest has centered on Rhodiola's effects on mood, fatigue, and cognitive function, with rosavins considered key active constituents. Several preclinical studies suggest that extracts containing rosavins may influence neurotransmitter levels, including dopamine, in the brain. For example, animal studies have reported increased dopamine levels in the cerebral cortex and hypothalamus after administration of Rhodiola extracts. Small human trials indicate potential benefits for stress-related fatigue and depressive symptoms, conditions sometimes associated with dopamine dysregulation. However, these studies generally use whole-plant extracts rather than isolated rosavins, and direct evidence linking rosavins specifically to modulation of the dopamine system in humans is lacking. The mechanism is hypothesized to involve inhibition of monoamine oxidase and modulation of dopamine release, but this is not conclusively proven in clinical settings. In summary, there is preliminary scientific evidence suggesting an effect on the dopamine system, but the evidence is indirect, mostly preclinical, and not robustly validated in humans for rosavins specifically.

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