Rosavins are a group of compounds found in Rhodiola rosea, a traditional adaptogenic herb. The main rosavins include rosavin, rosarin, and rosin. Rhodiola rosea has a long history of use in traditional medicine, particularly in Russia and Scandinavia, to combat fatigue and enhance physical and mental performance. Modern scientific research has explored its potential effects on neurotransmitter systems, including dopamine.

Several preclinical studies (mainly in animals and in vitro) suggest that extracts of Rhodiola rosea can influence levels of dopamine, serotonin, and norepinephrine in the brain, potentially through inhibition of monoamine oxidase and reuptake transporters. Some small human studies have shown that Rhodiola rosea supplementation may improve symptoms of fatigue, stress, and cognitive function, which are indirectly related to dopamine system activity. However, direct evidence that rosavins specifically support the dopamine body system in humans is limited.

Systematic reviews note that while Rhodiola rosea appears to have adaptogenic effects and may modulate neurotransmitter activity, most clinical trials are small, of short duration, and often use whole root extracts rather than isolated rosavins. Thus, while there is a plausible scientific basis and some preliminary evidence, the strength of evidence supporting the use of rosavins for direct dopamine system support is currently modest.