Evidence supporting the use of: Sarcosine
For the body system: Dopamine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sarcosine, also known as N-methylglycine, is a naturally occurring amino acid derivative. Its primary scientific relevance in relation to the dopamine system stems from its role as a glycine transporter-1 (GlyT1) inhibitor, which increases glycine levels in the synaptic cleft. Glycine is a co-agonist at the NMDA receptor, and NMDA receptor function is involved in modulating dopaminergic neurotransmission. Sarcosine has been studied primarily in the context of schizophrenia and cognitive function, with some small clinical trials suggesting that it may improve negative and cognitive symptoms, potentially through modulating glutamatergic and indirectly dopaminergic activity. However, direct evidence that sarcosine "supports the dopamine body system" in the sense of directly enhancing dopaminergic neurotransmission is limited. Most studies focus on its effects on NMDA receptors and downstream effects, rather than direct dopamine release or receptor sensitivity.

In summary, there is some scientific support (albeit moderate and indirect) for sarcosine influencing dopaminergic systems via glutamatergic modulation. It is not a traditional remedy for dopamine support, nor is it widely used outside of research settings or some cognitive health supplements. The evidence base is limited and mostly pertains to psychiatric populations rather than healthy individuals seeking to "support" dopamine function.

More about Sarcosine
More about Dopamine

Other body systems supported by Sarcosine

Brain
Dopamine

Products containing Sarcosine

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