Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Deglycyrrhizinated licorice (DGL) is primarily justified for use in duodenal ulcers based on limited scientific evidence, along with a long history of traditional use. DGL is a processed form of licorice root in which glycyrrhizin—a compound associated with adverse effects such as hypertension—has been removed, making it safer for long-term use. Several small clinical studies from the 1960s to the 1980s, as well as animal studies, have investigated DGL’s effects on peptic ulcers (including duodenal ulcers). These studies suggest that DGL may help increase mucus production in the digestive tract, promote mucosal healing, and inhibit ulcer formation, possibly via stimulation of protective prostaglandins and enhancement of mucous secretion.

For example, a randomized controlled trial published in the British Medical Journal in 1968 showed that DGL was as effective as cimetidine (an H2 blocker) in healing chronic duodenal ulcers over a 6-week period. However, these studies are generally small, older, and not always well-controlled by modern standards. More recent, robust clinical evidence is lacking. Systematic reviews and meta-analyses typically conclude that DGL may be beneficial, but that evidence quality is low and further research is needed.

Therefore, while DGL’s use for duodenal ulcers is supported by some scientific studies and is considered relatively safe, the quality and quantity of evidence is limited, leading to a modest evidence rating.

More about deglycyrrhizinated licorice
More about Duodenal Ulcers

Other ingredients used for Duodenal Ulcers

aloe vera
cabbage leaf
turmeric
forsythia
marshmallow
mastic gum
slippery elm bark
zinc

Other health conditions supported by deglycyrrhizinated licorice

Duodenal Ulcers
Duodenal Ulcers

Products containing deglycyrrhizinated licorice

We currently have no products on Vitabase that contain this ingredient.