Evidence supporting the use of: Alstonia macrophylla
For the health condition: Dysentery

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Alstonia macrophylla, commonly known as the devil tree, has a long history of use in traditional medicine systems across South and Southeast Asia. Ethnomedical reports from India, Sri Lanka, and surrounding regions document its use for treating gastrointestinal disorders, including dysentery and diarrhea. The bark and leaves are the primary parts used, often prepared as decoctions or infusions. The rationale for its use in dysentery is based on its reputed astringent, anti-inflammatory, and antimicrobial properties, as described in traditional texts and by local practitioners. Several studies have reported the presence of alkaloids, flavonoids, and other phytochemicals in the plant, which may contribute to these traditional effects.

However, while in vitro and animal studies have demonstrated some antibacterial and anti-inflammatory activity of Alstonia macrophylla extracts, direct high-quality clinical trials in humans for dysentery are lacking. The evidence for efficacy remains largely anecdotal and based on traditional use, with limited scientific validation. Thus, while its use is justified by tradition and some preliminary scientific rationale, rigorous clinical evidence is currently insufficient.

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