Evidence supporting the use of: Cannabinoids
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabinoids, including compounds such as THC and CBD from the cannabis plant, have been explored as potential treatments for dysmenorrhea (painful menstruation) due to their analgesic and anti-inflammatory properties. Scientific interest arises from the endocannabinoid system's role in modulating pain and inflammation. Some studies suggest that cannabinoids can reduce chronic pain, and preclinical evidence indicates that they may affect uterine contractility and pain perception. However, direct clinical evidence specifically supporting the use of cannabinoids for dysmenorrhea is limited. Most of the available data are extrapolated from studies on general chronic pain, neuropathic pain, or other gynecological conditions. A few small surveys and observational studies have reported that some women use cannabis products for menstrual pain relief and report subjective benefits. Nevertheless, high-quality randomized controlled trials in this population are lacking, and concerns remain regarding the safety, dosing, and side effect profiles of cannabinoids. Major gynecological organizations do not currently recommend cannabinoids as first-line therapy for dysmenorrhea, citing insufficient clinical evidence. In summary, while there is a plausible scientific rationale and some indirect and anecdotal evidence, robust clinical validation is not yet established.

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