Evidence supporting the use of: Vitamin B6 (various)
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its potential role in alleviating symptoms of dysmenorrhea, primarily due to its involvement in neurotransmitter synthesis (such as serotonin and dopamine) and its effect on hormone modulation. Several small randomized controlled trials and observational studies have evaluated the efficacy of vitamin B6 supplementation for menstrual pain. Some studies suggest that vitamin B6, alone or in combination with other micronutrients (like magnesium or vitamin E), might reduce the severity of menstrual cramps and associated symptoms such as mood disturbances. However, these studies are generally limited by small sample sizes, short durations, and varying dosages, making it difficult to draw robust conclusions. A 2016 systematic review noted that while there is some evidence for the benefit of vitamin B6 in premenstrual syndrome (PMS), the data specific to dysmenorrhea are limited and less conclusive. The proposed mechanisms for benefit include modulation of prostaglandin synthesis and neurotransmitter balance, which may influence pain perception. Major clinical guidelines do not currently recommend vitamin B6 as a first-line treatment for dysmenorrhea due to the low quality and quantity of evidence. In summary, vitamin B6 is sometimes used in clinical practice for dysmenorrhea, and there is limited scientific evidence suggesting a modest benefit, but the overall quality of evidence is low, and more rigorous studies are needed to confirm efficacy.

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