Evidence supporting the use of: Vitamin E (mixed alpha-tocopherol)
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (mixed alpha-tocopherol) has been studied for its potential benefit in supporting or treating dysmenorrhea (painful menstruation). Several randomized, placebo-controlled trials have investigated the effect of Vitamin E supplementation in women with primary dysmenorrhea. These studies generally used doses of 100-400 IU per day, administered a few days before and during menstruation. Results have shown modest reductions in pain intensity and duration compared to placebo, with some studies also reporting a decrease in the need for additional pain medications. The proposed mechanism is that Vitamin E, as an antioxidant, may help reduce the synthesis of prostaglandins in the endometrium, which are compounds involved in uterine contractions and menstrual pain. However, the overall quality of evidence remains limited by small sample sizes, short duration, and some methodological weaknesses. Systematic reviews and meta-analyses acknowledge a potential benefit but emphasize the need for larger, high-quality studies to confirm efficacy and establish optimal dosing. While Vitamin E is not part of standard medical guidelines for dysmenorrhea, its use is supported by a moderate amount of early scientific evidence rather than tradition or anecdote.

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