Aerva lanata, commonly known as Mountain Knot Grass, has a long history of use in traditional medicine systems, particularly in Ayurveda and Siddha. In these traditions, the plant is used for a variety of ailments, including dyspepsia (indigestion). Texts mention its use as a digestive aid, with preparations of the plant (whole or parts) administered to help alleviate symptoms such as stomach discomfort and bloating. The rationale in traditional practice is often based on the plant’s purported ability to "normalize" digestive function and reduce "heat" or "toxins" in the gastrointestinal tract.

However, scientific validation for the use of Aerva lanata specifically for dyspepsia is limited. While some pharmacological studies have shown the plant possesses antioxidant, anti-inflammatory, and mild antimicrobial properties, there is little direct clinical or preclinical evidence evaluating its efficacy for dyspepsia or related digestive disorders. Most published scientific studies focus on its diuretic, antiurolithiatic (anti-kidney stone), and hepatoprotective effects. Therefore, the support for its use in dyspepsia rests primarily on traditional knowledge rather than robust scientific data.

In summary, Aerva lanata is traditionally used to support digestive health and relieve dyspepsia, but scientific evidence for this indication remains sparse.