Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Neem (Azadirachta indica) has a long-standing history of use in traditional medicine systems such as Ayurveda and Unani, especially in South Asia. For digestive complaints like dyspepsia (indigestion), neem leaves, bark, and extracts have been used for their purported anti-inflammatory, antimicrobial, and carminative properties. Classical Ayurvedic texts describe neem as "tikta" (bitter), and such herbs are considered to stimulate digestive fire ("agni"), reduce toxins ("ama"), and relieve symptoms like bloating, flatulence, and mild stomach discomfort—hallmarks of dyspepsia.

Scientific studies on neem's direct effect on functional dyspepsia are limited. Some in vitro and animal studies suggest neem may have gastroprotective effects, reduce gastric acid secretion, and exhibit antimicrobial activity against pathogens implicated in gastrointestinal disturbances. However, robust clinical trials in humans specifically targeting dyspepsia are lacking. Most of the supportive evidence comes from case reports, ethnobotanical surveys, and extrapolation from neem's broader gastroprotective and anti-ulcer properties.

In summary, neem's use for dyspepsia is primarily justified by traditional and historical practice, with limited low-level scientific evidence. Individuals should exercise caution and consult healthcare professionals before using neem for digestive issues, especially given its potential toxicity in high doses.

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