Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Oregon grape (Mahonia aquifolium) has a long-standing history of use in traditional herbal medicine, particularly by Indigenous peoples of the Pacific Northwest and later by European herbalists. It has been employed as a bitter tonic to stimulate digestion and relieve symptoms associated with dyspepsia (indigestion), such as bloating, poor appetite, and mild stomach discomfort. The roots and bark contain alkaloids, primarily berberine, which have been thought to promote bile flow and improve digestive processes. Historical herbal texts from the 19th and early 20th centuries often recommend Oregon grape for sluggish digestion and liver complaints.

However, scientific evidence supporting Oregon grape’s efficacy for dyspepsia is limited. Most modern research focuses on its antimicrobial, anti-inflammatory, and hepatoprotective properties, not specifically on its effects in treating dyspepsia. Some in vitro and animal studies suggest berberine and related compounds can stimulate bile secretion and support liver function, potentially aiding digestion, but controlled human clinical trials for dyspepsia are lacking. Thus, the use of Oregon grape for dyspepsia remains primarily justified by traditional rather than scientific evidence, with a modest evidence rating reflecting the lack of rigorous clinical validation.

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Products containing oregon grape

Integrative Therapeutics Berberine Complex
Metagenics CandiBactin BR
Metagenics CandiBactin-BR