Evidence supporting the use of: Thymoquinone
For the health condition: Dyspepsia

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Thymoquinone is a bioactive compound found in Nigella sativa (black seed), which has a long history of use in traditional medicine systems, particularly in Middle Eastern, Indian, and North African cultures. In these traditions, Nigella sativa has been employed for a range of digestive complaints, including dyspepsia (indigestion), often as a carminative or tonic to relieve symptoms such as bloating, gas, and mild stomach discomfort.

While there is a substantial body of preclinical research on thymoquinone's pharmacological properties—such as anti-inflammatory, antioxidant, and gastroprotective effects—there is limited direct scientific evidence specifically validating the use of thymoquinone for dyspepsia in humans. Most clinical studies have focused on black seed oil or Nigella sativa as a whole, rather than isolated thymoquinone, and these studies are generally small and of variable quality. Some animal studies have shown that thymoquinone can protect gastric mucosa and reduce gastric acidity, which could potentially be relevant to dyspepsia, but these findings have not been robustly confirmed in clinical trials targeting dyspepsia.

In summary, the use of thymoquinone for dyspepsia is primarily supported by traditional use of Nigella sativa in folk medicine. Scientific evidence is preliminary and indirect, with insufficient high-quality clinical data to conclusively establish efficacy for this specific condition.

More about Thymoquinone
More about Dyspepsia

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Products containing Thymoquinone

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