Alstonia scholaris, also known as the devil tree, has been traditionally used in various systems of medicine, particularly Ayurveda and traditional folk medicine in parts of South and Southeast Asia. Its bark, leaves, and other parts have been utilized to treat a variety of ailments, including ear infections and earaches. Historical records and ethnobotanical surveys indicate that decoctions or infusions of the bark or leaves have been applied as ear drops or used to wash the ear in cases of pain or infection. The rationale in traditional practice is typically based on the plant's reputed anti-inflammatory, analgesic, and antimicrobial properties. However, while there are some in vitro and animal studies showing that extracts of Alstonia scholaris possess antimicrobial and anti-inflammatory effects, there is a lack of direct clinical evidence specifically supporting its efficacy in treating ear infections or earache in humans. No controlled clinical trials or robust pharmacological studies exist that focus on its application for otic conditions. Thus, its use for earache or infection is primarily justified by tradition, with scientific validation remaining limited to general bioactivity studies rather than targeted clinical research.