Bio Ecolian (proprietary) is a postbiotic ingredient, meaning it is a metabolite or product derived from probiotic bacteria. Specifically, Bio Ecolian is often described as an α-glucan oligosaccharide, which serves as a "biomimetic" postbiotic by supporting the skin's natural microbiota. There is growing scientific interest in the role of the skin microbiome in conditions like eczema (atopic dermatitis), where an imbalance in skin flora is commonly observed, often characterized by an overgrowth of Staphylococcus aureus and a reduction in microbial diversity.

Several in vitro and ex vivo studies have demonstrated that α-glucan oligosaccharides such as those found in Bio Ecolian can selectively promote the growth of beneficial skin microbes while inhibiting pathogenic bacteria. This may help restore the skin's barrier function and reduce inflammation, both key goals in eczema care. However, while these early findings are promising and there are some small clinical studies suggesting improvements in skin barrier integrity and hydration with postbiotic use, robust, large-scale randomized controlled trials specifically examining Bio Ecolian for eczema are lacking. Therefore, while its use is scientifically plausible and supported by mechanistic studies, the direct clinical evidence is still emerging.

In summary, Bio Ecolian’s use for eczema is based on scientific understanding of the skin microbiome and preclinical data, but the level of clinical evidence currently rates as moderate rather than strong.