Flavonoid glycosides, a class of polyphenolic compounds found in many plants, have been investigated for their potential benefits in inflammatory skin conditions, including eczema (atopic dermatitis). Their use is primarily justified by scientific research rather than longstanding traditional application for this specific condition. Flavonoids are known for their antioxidant, anti-inflammatory, and immunomodulatory properties, which are relevant to the pathophysiology of eczema, where oxidative stress and inflammation play significant roles.

Several in vitro and animal studies have shown that certain flavonoid glycosides (such as quercetin, rutin, and luteolin glycosides) can inhibit inflammatory mediators, reduce histamine release, and modulate immune responses. Some small-scale clinical studies and topical formulations containing flavonoids have reported improvements in symptoms like itchiness, redness, and skin barrier function in patients with eczema. However, robust, large-scale randomized controlled trials are lacking, and most of the evidence remains preclinical or from pilot studies.

In summary, while the anti-inflammatory effects of flavonoid glycosides provide a plausible scientific basis for their use in eczema, the overall quality and quantity of direct clinical evidence are still limited. Therefore, current support for their use in eczema is modest and rated as 2 on a 0-5 evidence scale.