Evidence supporting the use of: Lactobacillus casei
For the health condition: Eczema

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus casei is a probiotic bacterium that has been investigated for its potential to support or treat eczema (atopic dermatitis), primarily based on its effects on the gut microbiome and immune modulation. The scientific evidence for its effectiveness in eczema is limited but emerging. Several randomized controlled trials and systematic reviews have assessed various probiotic strains, including L. casei, for eczema prevention and symptom reduction, especially in children.

Some studies suggest that L. casei may reduce the incidence or severity of eczema by modulating immune responses, enhancing regulatory T-cell activity, and decreasing inflammatory cytokines. A few clinical trials report modest improvements in eczema severity scores in children who received L. casei supplements, particularly when given to pregnant mothers and infants at high risk for allergies. However, these benefits are not consistently observed across all studies, and effects may depend on the timing, combination with other probiotic strains, and host factors.

Systematic reviews and meta-analyses (e.g., Cuello-Garcia et al., 2015; Huang et al., 2017) conclude that while probiotics (including L. casei) may offer some preventive benefit for at-risk infants, the overall quality of evidence is low to moderate, and not all individuals benefit. Major allergy and dermatology organizations currently consider probiotics as a possible adjunctive therapy but do not strongly recommend them for routine eczema management due to inconsistent results.

In summary, L. casei is used to support eczema based on preliminary scientific evidence, but the strength of evidence is modest (rated 2/5), and further research is needed for definitive recommendations.

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