Macaranga indica is an herb traditionally used in several systems of folk medicine in South Asia, particularly in Ayurveda, where it has been prescribed for a variety of skin ailments, including eczema. The primary justification for its use in treating eczema is based on traditional knowledge and ethnomedicinal practices, rather than robust scientific validation.

Several ethnobotanical surveys and Ayurvedic texts cite the use of Macaranga indica leaves and extracts in formulations for treating skin inflammation, itching, and other dermatological complaints, which may include conditions resembling eczema. The plant is reputed to have anti-inflammatory and antimicrobial properties, which could theoretically benefit eczema sufferers. However, scientific studies specifically evaluating its efficacy for eczema (atopic dermatitis) are absent in the peer-reviewed literature as of 2024. While some preliminary research has explored the plant’s general anti-inflammatory and antioxidant activities, these findings have not been directly translated to clinical outcomes in eczema.

In summary, the use of Macaranga indica for eczema is primarily supported by traditional and ethnobotanical evidence, with very limited or no direct scientific studies confirming its efficacy or safety for this specific condition.