Self-Heal (Prunella vulgaris) has a long history of use in traditional herbal medicine, particularly in Europe and Asia, for various inflammatory skin conditions, including eczema. Traditional herbalists have often applied Self-Heal topically or used it in washes, citing its purported anti-inflammatory, astringent, and wound-healing properties. Some historical texts and ethnobotanical reports mention its use for soothing irritated skin and promoting the healing of minor wounds, which could encompass eczema-like symptoms.

However, scientific evidence specifically supporting the efficacy of Self-Heal for eczema is limited. There are a few laboratory studies that suggest Prunella vulgaris extracts have anti-inflammatory and antioxidant effects, but these are primarily in vitro or animal studies and do not directly address eczema in humans. No well-conducted clinical trials have established its benefits for atopic dermatitis or eczema. As such, its use for eczema is justified primarily by tradition rather than robust scientific validation, and the evidence supporting its efficacy is weak.