Evidence supporting the use of: Bioflavonoid
For the health condition: Edema

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bioflavonoids, also known as flavonoids, are plant-derived compounds known for their antioxidant and vasoprotective properties. Their use in supporting or treating edema, particularly chronic venous insufficiency (CVI) and related vascular conditions, is supported by some scientific evidence, mainly from clinical studies in Europe. Flavonoids such as diosmin and hesperidin have been included in "micronized purified flavonoid fraction" (MPFF) formulations, which are prescribed for symptoms of venous insufficiency, including edema, leg heaviness, and pain. Several randomized controlled trials and meta-analyses suggest that such preparations can reduce leg swelling and improve symptoms compared to placebo, likely due to their ability to improve capillary resistance, decrease capillary permeability, and enhance venous tone. The European Medicines Agency recognizes certain flavonoids for symptomatic relief of CVI, although the effect size may be modest.

However, the evidence is not uniformly strong: some studies are of moderate quality, and results can be inconsistent depending on the specific type of flavonoid and formulation. There is less robust evidence for the use of general flavonoids in other forms of edema not related to venous insufficiency. Therefore, while there is scientific support for the use of certain bioflavonoids in vascular-related edema, especially in CVI, the overall evidence base is moderate (3/5).

More about Bioflavonoid
More about Edema

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bamboo
bearberry
bilberry
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bromelain
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burdock
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hesperidin
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jujube
lemon
lophatherum leaf
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mannitol
moringa
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nettle
papain
parsley
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pine bark
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scrophularia root
serratiopeptidase
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trypsin
seaweed
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xanthium (cockleburs)
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alpinia galangal
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commiphora
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swertia
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goldenrod
prickly ash
lemongrass
silk tree
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solomon's seal
siler root
amber
dioscorea
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sweet flag
hyacinth bean
morinda
cornsilk
buchu
birch
couch grass
sheep's sorrel
queen of the meadow
hydrangea
purslane
gentiana macrophylla
cleavers
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white oak
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Achyranthes
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banana
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Products containing Bioflavonoid

We currently have no products on Vitabase that contain this ingredient.