Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrus bioflavonoids, particularly diosmin and hesperidin, have some scientific backing for their use in the management of edema, especially when it is related to chronic venous insufficiency (CVI). Edema, or swelling caused by fluid accumulation, is a common symptom of CVI, and certain bioflavonoids have been studied for their ability to improve venous tone and capillary resistance. Several randomized controlled trials and meta-analyses suggest that micronized purified flavonoid fraction (MPFF), a formulation containing diosmin and hesperidin (derived from citrus), can reduce leg edema and improve symptoms like heaviness and discomfort in patients with venous disorders.

The proposed mechanisms include antioxidant effects, protection of the vascular endothelium, and reduction of capillary permeability, all of which help prevent the leakage of fluid into surrounding tissues. Regulatory bodies in some countries recognize MPFF as a treatment option for venous insufficiency-related edema. However, it is important to note that the evidence is moderate and largely limited to venous edema; there is insufficient data to support the use of citrus bioflavonoids for edema from other causes (such as heart, kidney, or liver failure). The overall quality of evidence is rated as moderate (level 2 out of 5), as more large-scale and high-quality trials are needed to firmly establish efficacy and optimal dosing.

More about citrus bioflavonoids
More about Edema

Other ingredients used for Edema

Other health conditions supported by citrus bioflavonoids

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