Evidence supporting the use of: Glycyrrhizic acid
For the health condition: Edema

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Glycyrrhizic acid, a primary active compound found in licorice root (Glycyrrhiza glabra), has a long history of use in traditional medicine systems such as Traditional Chinese Medicine (TCM) and Ayurveda. In these traditions, licorice root preparations have been used for a variety of ailments, including as a remedy for swelling and edema. The rationale in traditional contexts often involves its perceived ability to "harmonize" herbal formulas and reduce toxicity, as well as its purported anti-inflammatory properties.

However, scientific evidence supporting the efficacy of glycyrrhizic acid specifically for treating or supporting edema is lacking. Modern pharmacological studies primarily focus on glycyrrhizic acid's anti-inflammatory, antiviral, and hepatoprotective effects. In fact, chronic or excessive intake of glycyrrhizic acid can lead to pseudoaldosteronism, a condition characterized by sodium retention, potassium loss, hypertension, and sometimes increased fluid retention—essentially worsening or even causing edema rather than alleviating it. This effect is due to glycyrrhizic acid's inhibition of 11β-hydroxysteroid dehydrogenase type 2, leading to increased cortisol activity at mineralocorticoid receptors.

In summary, while glycyrrhizic acid is used traditionally in herbal medicine for symptoms that may include edema, there is little to no scientific support for this use, and pharmacological data suggest a risk of exacerbating fluid retention. Therefore, its use for edema is rooted primarily in tradition, with minimal scientific validation.

More about glycyrrhizic acid
More about Edema

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Products containing glycyrrhizic acid

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