Polygonatum, commonly known as Solomon's Seal, has a long history of use in traditional Chinese medicine (TCM) and other ethnomedical systems. In TCM, Polygonatum species (notably Polygonatum sibiricum and Polygonatum odoratum) are used for a range of health concerns, including nourishing yin, moistening dryness, and supporting lung and kidney function. Edema (fluid retention) is sometimes addressed in TCM with Polygonatum as part of complex herbal formulas. The rationale is based on its supposed ability to strengthen the spleen and kidneys, thus promoting fluid balance in the body.

However, direct scientific evidence supporting Polygonatum’s efficacy for treating or supporting edema is limited. Most available studies focus on its potential anti-inflammatory, antioxidant, and immunomodulatory properties. There are few, if any, modern clinical trials specifically evaluating its effects on edema in humans. Some animal and in vitro studies suggest possible diuretic effects, but these findings have not been robustly replicated or validated in clinical settings.

In summary, the use of Polygonatum for edema is primarily rooted in traditional medicine rather than modern scientific validation. The evidence rating is low (2/5), reflecting the lack of direct clinical studies despite a strong historical precedent in herbal practice.