Evidence supporting the use of: Vitamin B6 (pyridoxal 5 phosphate)
For the health condition: Emotional Sensitivity

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (in its active form, pyridoxal 5’-phosphate) has some scientific rationale for being used to support emotional health, including emotional sensitivity. B6 is a coenzyme involved in the synthesis of several neurotransmitters, including serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which are implicated in mood regulation. Several studies have observed associations between low B6 status and symptoms such as irritability, depression, and mood swings, suggesting a potential link to emotional sensitivity. A small number of controlled trials have examined B6 supplementation for mood symptoms, with some showing mild benefits for premenstrual syndrome (PMS)-related mood changes and for depressive symptoms, particularly when combined with other B vitamins. However, evidence specifically targeting "emotional sensitivity" as a distinct clinical entity is lacking, and most studies focus on broader mood disorders or symptoms. The quality of evidence is moderate at best, with some positive findings but also inconsistencies and methodological limitations. Overall, while there is a plausible biochemical basis and some preliminary clinical support for the use of B6 in emotional health, robust evidence for its use specifically for emotional sensitivity remains limited. Further well-designed studies are needed to clarify its role in this context.

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