Evidence supporting the use of: Vitamin B6 (unspecified)
For the health condition: Emotional Sensitivity

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has some scientific evidence supporting its role in mood regulation, though the connection to "emotional sensitivity" specifically is less direct. Vitamin B6 is a cofactor in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which are involved in mood and emotional regulation. Several studies have explored the effect of B6 supplementation on premenstrual syndrome (PMS), where mood symptoms—including increased emotional sensitivity—are common. Some randomized controlled trials have reported beneficial effects of B6 in reducing PMS-related mood disturbances, though results are inconsistent and effect sizes are generally modest.

Systematic reviews and meta-analyses suggest a possible, but not definitive, benefit of B6 supplementation for mood symptoms in PMS. There is limited evidence for its use in other populations or for generalized emotional sensitivity outside of PMS. Overall, while there is a biochemical rationale and a modest clinical signal in specific contexts, the evidence base is not robust, and further research is needed to clarify the effectiveness of B6 for emotional sensitivity in the general population.

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