Evidence supporting the use of: Curcuminoids
For the health condition: Endometriosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcuminoids, the primary active compounds in turmeric (Curcuma longa), have been studied for their anti-inflammatory, antioxidant, and anti-proliferative properties. There is some scientific evidence suggesting a potential benefit of curcuminoids in managing endometriosis. Preclinical studies, primarily in animal models and cell cultures, have demonstrated that curcumin can suppress the proliferation of endometrial cells, reduce inflammatory cytokine levels, and inhibit angiogenesis, all of which are processes implicated in the development and progression of endometriosis. For example, a 2013 Journal of Cellular Physiology study found that curcumin inhibited the migration and invasion of endometrial stromal cells in vitro. Animal studies have also indicated a reduction in lesion size and inflammation with curcumin supplementation.

However, clinical evidence in humans is very limited. There are few, if any, robust randomized controlled trials examining curcuminoids specifically for endometriosis in women. Most available data are extrapolated from laboratory and animal research, and thus the evidence is considered preliminary. Curcuminoids are not part of standard medical therapy for endometriosis but are sometimes used as adjuncts due to their overall anti-inflammatory effects and established safety profile in dietary use. In summary, while there is a scientific rationale and early evidence for curcuminoids in endometriosis, high-quality human data is lacking, meriting a low-to-moderate evidence rating.

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