Evidence supporting the use of: DIM (diindolylmethane)
For the health condition: Endometriosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and cabbage. Its use for endometriosis is based on its ability to modulate estrogen metabolism. Endometriosis is an estrogen-dependent condition, and DIM has been shown in laboratory and animal studies to promote the formation of less potent estrogen metabolites, potentially reducing estrogenic stimulation of endometrial tissue.

Some preliminary clinical and preclinical studies suggest that DIM may help balance estrogen activity by increasing the ratio of 2-hydroxyestrone to 16α-hydroxyestrone, favoring pathways linked to reduced estrogenic activity. This theoretical benefit has led some integrative practitioners to use DIM for endometriosis management, aiming to reduce symptoms and lesion growth.

However, robust clinical trials in humans with endometriosis are lacking. Most evidence is extrapolated from studies on estrogen metabolism or on other estrogen-driven conditions. Therefore, while the rationale for DIM's use in endometriosis is scientifically plausible, direct evidence in this population remains limited and of low quality. The overall level of evidence supporting DIM for endometriosis is currently rated as low (2/5), and its use should be considered experimental pending further research.

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