Evidence supporting the use of: Fatty acids
For the health condition: Endometriosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

There is some scientific evidence suggesting that fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may have a beneficial effect in supporting the management of endometriosis. The rationale is based on their anti-inflammatory properties, as endometriosis is characterized by chronic inflammation and immune dysregulation. Several observational and interventional studies have reported that higher intake of omega-3 fatty acids is associated with a reduced risk of developing endometriosis or with an improvement in symptoms such as pelvic pain. For example, a prospective study published in the American Journal of Epidemiology (2010) found that women with higher dietary intake of omega-3 fatty acids had a lower risk of endometriosis, while higher trans-fat intake was associated with increased risk. Small clinical trials have shown that omega-3 supplementation may reduce pain scores in women with endometriosis, though results are mixed and sample sizes are often limited.

Despite this, the evidence is not robust; systematic reviews and meta-analyses conclude that while omega-3 fatty acids may have potential as an adjunct therapy, more high-quality, large-scale clinical trials are needed to confirm their efficacy and establish optimal dosing. Currently, fatty acids are not considered a first-line treatment but may be recommended as a supportive approach due to their safety profile and potential anti-inflammatory effects.

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