Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Genistein is an isoflavone phytoestrogen predominantly found in soy products. Its interest in endometriosis stems from its ability to modulate estrogen receptor activity, as endometriosis is an estrogen-dependent condition. Some in vitro and animal studies have suggested that genistein may inhibit proliferation of endometrial tissue and reduce inflammatory markers associated with endometriosis. For example, research using rodent models has demonstrated that genistein can suppress the growth of ectopic endometrial tissue, potentially through downregulation of estrogen-responsive gene expression and inhibition of angiogenesis. Additionally, genistein exhibits anti-inflammatory and antioxidant properties, which may theoretically confer benefits in reducing the chronic pelvic inflammation characteristic of endometriosis. However, clinical evidence in humans remains limited and inconclusive. Most studies are preclinical, and only a small number of pilot clinical trials or observational studies have examined the effects of genistein or soy isoflavones on endometriosis symptoms or progression. Furthermore, as a phytoestrogen, genistein may exert both estrogenic and anti-estrogenic effects depending on endogenous hormone levels, which complicates its therapeutic profile. Until robust, well-controlled human trials are conducted, the evidence supporting genistein’s use in endometriosis is preliminary. Thus, while there is a scientific rationale and some experimental support, current evidence is not strong enough to recommend genistein as a standard therapy for endometriosis.

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Other ingredients used for Endometriosis

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Products containing genistein

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