Evidence supporting the use of: 7-Keto-DHEA
For the health condition: Energy (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

7-Keto-DHEA (7-oxo-dehydroepiandrosterone-acetate) is a metabolite of DHEA, a hormone naturally produced by the adrenal glands. Its use as a supplement to support or treat low energy is primarily justified by some scientific research, though the evidence base is limited and not robust. Several small-scale clinical studies have evaluated 7-keto-DHEA for its potential to increase metabolic rate and promote weight loss, which could indirectly influence energy levels. For instance, a few randomized controlled trials have shown that 7-keto supplementation may increase resting metabolic rate in overweight adults without affecting heart rate or blood pressure. The presumed mechanism involves increased thermogenesis and upregulation of certain thermogenic enzymes, which could theoretically improve subjective feelings of energy or combat fatigue.

However, there is a lack of large, high-quality trials directly assessing its effects on energy levels or fatigue in the general population. Most studies focus on metabolic rate and weight management, with energy or fatigue often assessed only as secondary endpoints or not at all. The evidence supporting 7-keto-DHEA for improved energy is therefore preliminary and should be interpreted cautiously. While some users report subjective improvements, these claims are not yet substantiated by strong clinical data. Thus, the scientific support for 7-keto-DHEA as a remedy for lack of energy is limited (rated 2/5), and further research is needed to confirm its efficacy and safety for this specific purpose.

More about 7-Keto-DHEA
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Other ingredients used for Energy (lack of)

7-Keto-DHEA
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acetyl l-carnitine
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alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
amylopectin
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biotin
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capsaicinoids
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coenzyme Q10 (CoQ10)
coffee fruit
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l-carnitine
l-glutamine
l-glycine
l-leucine
l-tyrosine
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malic acid
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medium chain triglycerides (MCT)
microbial enzymes (proprietary)
milk
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nettle
pantothenic acid (vitamin B5)
pollen
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succinic acid
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vegetable blend (proprietary)
velvet bean
vitamin B
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zinc
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commiphora
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siler root
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electrolytes blend (proprietary)
trace minerals
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algae
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berry
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cola nut
Dendrobium
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