Evidence supporting the use of: Alpha-Ketoglutarate
For the health condition: Energy (lack of)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Ketoglutarate (AKG) is an intermediate in the Krebs (citric acid) cycle, a fundamental cellular process responsible for generating energy (ATP) in the mitochondria. This biochemical role provides a scientific rationale for its proposed use in supporting energy metabolism. Some preclinical studies and limited clinical trials suggest that AKG supplementation may influence cellular energy production and reduce fatigue, particularly in specific contexts such as chronic kidney disease or in athletes during intense exercise. For example, AKG has been studied as a component of oral supplements intended to reduce catabolism and muscle wasting, with some reports of improved energy or reduced fatigue in these populations. However, robust clinical evidence supporting AKG supplementation for general energy enhancement in healthy individuals is lacking. Most human studies are small, with methodological limitations and inconsistent results. Theoretical benefits are often extrapolated from its role in metabolic pathways rather than from direct clinical trials measuring improvements in energy levels. Overall, while there is a plausible biochemical basis and some early research, the scientific evidence supporting the use of alpha-ketoglutarate for treating or supporting lack of energy is limited and not yet conclusive.

More about Alpha-Ketoglutarate
More about Energy (lack of)

Other ingredients used for Energy (lack of)

7-Keto-DHEA
acai berry
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
aspartic acid
beta-alanine
biotin
black pepper
bасора
caffeine
capsaicinoids
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
eleuthero
folate
fructose
ginseng
greens blend (proprietary)
guarana
guayusa
l-alanyl-l-glutamine
l-carnitine
l-glutamine
l-glycine
l-leucine
l-tyrosine
maca
magnesium
malic acid
maltodextrin
medium chain triglycerides (MCT)
microbial enzymes (proprietary)
milk
Acetyl-L-Tyrosine
nettle
pantothenic acid (vitamin B5)
pollen
protein
pyrroloquinoline disodium salt
rhodiola
rosemary
sage
shiitake mushroom
black ginger
sphaeranthus indicus
spirulina
succinic acid
tongkat ali
almond fruit
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
whey protein
zinc
suma
jiaogulan
alpinia galangal
commiphora
bee pollen
lemongrass
siler root
cistanche
sweet flag
electrolytes blend (proprietary)
trace minerals
yerba mate
wheat germ
algae
1,3,7-Trimethylpurine-2,6-dione
Aralia
akebia
Alpha polylactate
Antler
Agastache
Arginine Creatine
Ardisia
Arginine malate
Anamu
Areca
adenosine triphosphate (ATP)
Algal protein
Amor seco
Arginine silicate
Atractylone
Animal protein
Beta Phenethylalamine
Blackthorn
Beta-hydroxybutyrate
Beef liver
Bovine Protein
berry
Ba Ji Tian
Borassus Palm
Borassus aethiopum
banana
Baobab
Borneol
Chia seed
Coconut
Cinnamomum
Coenzyme A
coconut oil
Codonopsis
Cynomorium
Catecholamine
Chlorophytum
Chuchuhuasi
Curcumen
Coca
Chicken
cola nut
Dendrobium
Deer Root
Deer Velvet
Dragonhead
Dextrates
D-Ribose
Dextrose
Erodium cicutarium
Egg
Elk antler
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
Egg protein
glucose
Ketone Salts
Milk Protein
peanut
Wheat

Products containing Alpha-Ketoglutarate

We currently have no products on Vitabase that contain this ingredient.