Evidence supporting the use of: Arginine silicate
For the health condition: Energy (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Arginine silicate is a compound that combines L-arginine, an amino acid, with silicon. Its use in supporting or treating lack of energy is based on several small-scale clinical studies, though the overall evidence remains limited. Arginine is a precursor for nitric oxide (NO), a molecule that plays a critical role in vasodilation (widening of blood vessels), thereby potentially improving blood flow and oxygen delivery to tissues. Improved circulation may contribute to enhanced physical performance and reduced feelings of fatigue.
A few studies, such as those published in the Journal of the International Society of Sports Nutrition (2015, 2016), have shown that arginine silicate supplementation can improve perceived energy, mental focus, and exercise performance in athletes and healthy adults. These studies are promising but involve relatively small sample sizes and short durations. The mechanism is thought to be linked to increased nitric oxide production and improved silicon bioavailability, supporting vascular health and possibly cognitive function.
However, there is a lack of large, long-term randomized controlled trials directly evaluating arginine silicate for general fatigue or chronic lack of energy in non-athletic populations. Most evidence pertains to short-term improvements in exercise performance or mental focus. As such, while there is some scientific rationale and preliminary evidence, the overall strength of data is moderate to low (2/5). Further research is needed to conclusively establish its efficacy for treating or supporting energy in the general population.
Other ingredients used for Energy (lack of)
1,3,7-Trimethylpurine-2,6-dione7-Keto-DHEA
Acai berry
Acetyl L-carnitine
Acetyl-L-Tyrosine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Agastache
Akebia
Algae
Algal protein
Almond fruit
Alpha D-ribofuranose
Alpha polylactate
alpha-ketoglutarate (AKG)
alpinia galangal
amino acids
Amor seco
anamu
animal protein
antler
Aralia
Ardisia
Areca
arginine creatine
Arginine malate
Arginine silicate
ashwagandha
aspartic acid
atractylone
ba ji tian
banana
baobab
bee pollen
Beef liver
berry
beta phenethylalamine
beta-alanine
beta-hydroxybutyrate
biotin
black ginger
black pepper
blackthorn
Borassus aethiopum
borassus palm
borneol
bovine protein
bасора
caffeine
capsaicinoids
catecholamine
chia seed
Chlorophytum
chuchuhuasi
Cinnamomum
cistanche
coca
coconut
coconut milk
coconut oil
Codonopsis
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
cola nut
commiphora
cordyceps
creatine monohydrate
curcumen
Cynomorium
D-Ribose
deer root
deer velvet
Dendrobium
dextrates
dextrose
dragonhead
ecdysterone
egg
Egg protein
electrolytes blend (proprietary)
eleuthero
elk antler
ephedrine
Erodium cicutarium
Ethyl-Alpha-Guanido-Methyl-Ethanoate
Eurycoma Longifolia
eurycomanone
folate
fungus
gamma-butyrobetaine
garden cress
ginseng
glucose
GMS-ribose
greens blend (proprietary)
guarana
Guaranine
guayusa
Herb Robert
Higenamine
Ilex
jiaogulan
jungli-bean
ketone salts
ketosterones
kola nut
L-alanyl-L-glutamine
l-carnitine
L-glutamine
L-glycine
L-leucine
l-tyrosine
lemongrass
lipids
maca
macaenes
macamides
magnesium
malic acid
maral root
medium chain triglycerides (MCT)
Methylliberine
Microbial enzymes (proprietary)
Milk
Milk Protein
Ming Dang Shen
Mushroom
Nettle
Orchis latifolia
ornithine L-aspartic acid
Oroxylum indicum
Osha
oxaloacetic acid
pantothenic acid (vitamin B5)
paraxanthine
peanut
Petiveria
Phytoecdysteroid
Plankton
pollen
Polygonatum
protein
Pseudostellaria
pyrroloquinoline disodium salt
pyrroloquinoline quinone
Rhodiola
ribose
robusta coffee
rosemary
Rubia yunnanensis
Rubiaceae
Safed musli
sage
Sarivan
shiitake mushroom
Sichuan Lovage
Sida cordifolia
siler root
Southern Tsangshu
Sphaeranthus indicus
spirulina
succinic acid
Sulbutiamine
suma
sweet flag
Synephrine
Tea
Teacrine
Terminalia
Theacrine
Theobromine
Thylakoid
Tongkat ali
trace minerals
Trichilia catigua
Trichopus zeylanicus
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
Wheat
wheat germ
Whey protein
Wulinshen
Yerba mate
Yuzu
Zedoary
Zinc
Zingiberene
Other health conditions supported by Arginine silicate
Athletic and Exercise AidsCardiovascular Disease
Circulation (poor)
Circulation (to the brain)
Energy (lack of)
Exercise
Hypertension
Peripheral Neuropathy