Evidence supporting the use of: Atractylone
For the health condition: Energy (lack of)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Atractylone is a major bioactive compound found in Atractylodes macrocephala, a key herb in Traditional Chinese Medicine (TCM). Historically, this herb has been used to tonify the "Spleen Qi," which in TCM theory is closely linked to energy, vitality, and digestive strength. The traditional use of Atractylodes rhizome includes formulas intended to address symptoms such as fatigue, weakness, and poor appetite—conditions interpreted as manifestations of Qi deficiency. While this traditional framework does not directly align with modern biomedical definitions of energy metabolism or fatigue syndromes, it has provided the basis for the inclusion of atractylone-containing herbs in various energy-supporting herbal formulations for centuries.

Scientific validation specifically for atractylone itself in the context of increasing human energy or directly treating fatigue is limited. Some preclinical studies have reported that atractylone may possess anti-inflammatory, immunomodulatory, and gastrointestinal protective effects, which could conceivably contribute to an improved sense of well-being or vitality. However, clinical trials specifically assessing atractylone or Atractylodes extracts for the treatment of low energy or fatigue in humans are largely lacking. The evidence therefore predominantly rests on traditional use, with a modest (rated 2/5) level of support based on limited scientific plausibility rather than direct clinical proof.

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Products containing atractylone

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