Evidence supporting the use of: Coenzyme A
For the health condition: Energy (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Coenzyme A (CoA) is an essential cofactor involved in numerous biochemical pathways, particularly those related to energy metabolism, such as the citric acid cycle (Krebs cycle) and the beta-oxidation of fatty acids. Its role in converting carbohydrates, fats, and proteins into ATP—the body’s primary energy currency—is well-documented in biochemistry. However, while the physiological importance of CoA is scientifically established, evidence supporting the use of supplemental Coenzyme A to treat or improve symptoms of low energy in healthy individuals is limited.
Most clinical research on energy supplementation focuses on related compounds like acetyl-L-carnitine or B vitamins (which are involved in CoA synthesis via pantothenic acid), rather than direct CoA supplementation. There are very few clinical trials assessing the efficacy of CoA supplements for fatigue or energy enhancement, and those that exist are generally small or methodologically weak. The body typically synthesizes sufficient CoA from dietary pantothenic acid; true deficiency is rare and usually associated with severe malnutrition.
In summary, while the biochemical rationale for CoA’s involvement in energy production is clear, there is insufficient clinical evidence to support the use of CoA supplements for treating lack of energy in otherwise healthy individuals. The evidence rating is therefore low, with a score of 2, reflecting a strong theoretical basis but limited direct clinical validation.
Other ingredients used for Energy (lack of)
7-Keto-DHEAacai berry
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
aspartic acid
beta-alanine
biotin
black pepper
bасора
caffeine
capsaicinoids
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
eleuthero
folate
fructose
ginseng
greens blend (proprietary)
guarana
guayusa
l-alanyl-l-glutamine
l-carnitine
l-glutamine
l-glycine
l-leucine
l-tyrosine
maca
magnesium
malic acid
maltodextrin
medium chain triglycerides (MCT)
microbial enzymes (proprietary)
milk
Acetyl-L-Tyrosine
nettle
pantothenic acid (vitamin B5)
pollen
protein
pyrroloquinoline disodium salt
rhodiola
rosemary
sage
shiitake mushroom
black ginger
sphaeranthus indicus
spirulina
succinic acid
tongkat ali
almond fruit
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
whey protein
zinc
suma
jiaogulan
alpinia galangal
commiphora
bee pollen
lemongrass
siler root
cistanche
sweet flag
electrolytes blend (proprietary)
trace minerals
yerba mate
wheat germ
algae
1,3,7-Trimethylpurine-2,6-dione
Aralia
akebia
Alpha polylactate
Antler
Agastache
Arginine Creatine
Ardisia
Arginine malate
Anamu
Areca
adenosine triphosphate (ATP)
Algal protein
Amor seco
Arginine silicate
Atractylone
Animal protein
Beta Phenethylalamine
Blackthorn
Beta-hydroxybutyrate
Beef liver
Bovine Protein
berry
Ba Ji Tian
Borassus Palm
Borassus aethiopum
banana
Baobab
Borneol
Chia seed
Coconut
Cinnamomum
Coenzyme A
coconut oil
Codonopsis
Cynomorium
Catecholamine
Chlorophytum
Chuchuhuasi
Curcumen
Coca
Chicken
cola nut
Dendrobium
Deer Root
Deer Velvet
Dragonhead
Dextrates
D-Ribose
Dextrose
Erodium cicutarium
Egg
Elk antler
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
Egg protein
glucose
Ketone Salts
Milk Protein
peanut
Wheat