Evidence supporting the use of: Creatine phosphate
For the health condition: Energy (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Creatine phosphate (also called phosphocreatine) is scientifically validated as a means to support energy, particularly in the context of muscle energy metabolism. Phosphocreatine acts as a rapid reserve of high-energy phosphates in skeletal muscle and the brain, helping to regenerate adenosine triphosphate (ATP), which is the primary energy currency of the cell. During short bursts of intense activity, such as sprinting or weightlifting, the phosphocreatine system provides immediate ATP, allowing muscles to sustain contraction for a few extra seconds before other metabolic pathways take over.
Supplemental creatine monohydrate (which boosts intramuscular creatine phosphate levels) has been extensively studied and shown to enhance performance in high-intensity, short-duration activities. There is also evidence that creatine supplementation can help reduce fatigue and improve recovery in certain populations, including older adults and individuals with muscle or neurological diseases. However, while creatine loading increases creatine phosphate availability and can reduce perceived fatigue during intense exercise, its effects on general "energy" or fatigue in everyday, non-athletic settings are less well established.
Clinical use of creatine or creatine phosphate for treating medical conditions like chronic fatigue syndrome or general energy deficiency is less supported, and most evidence pertains to athletic and neuromuscular contexts. Therefore, the evidence rating is moderate (3/5), strongly supporting specific uses but less so for broad claims of “energy” enhancement in non-athletic contexts.
Other ingredients used for Energy (lack of)
7-Keto-DHEAacai berry
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
aspartic acid
beta-alanine
biotin
black pepper
bасора
caffeine
capsaicinoids
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
eleuthero
folate
fructose
ginseng
greens blend (proprietary)
guarana
guayusa
l-alanyl-l-glutamine
l-carnitine
l-glutamine
l-glycine
l-leucine
l-tyrosine
maca
magnesium
malic acid
maltodextrin
medium chain triglycerides (MCT)
microbial enzymes (proprietary)
milk
Acetyl-L-Tyrosine
nettle
pantothenic acid (vitamin B5)
pollen
protein
pyrroloquinoline disodium salt
rhodiola
rosemary
sage
shiitake mushroom
black ginger
sphaeranthus indicus
spirulina
succinic acid
tongkat ali
almond fruit
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
whey protein
zinc
suma
jiaogulan
alpinia galangal
commiphora
bee pollen
lemongrass
siler root
cistanche
sweet flag
electrolytes blend (proprietary)
trace minerals
yerba mate
wheat germ
algae
1,3,7-Trimethylpurine-2,6-dione
Aralia
akebia
Alpha polylactate
Antler
Agastache
Arginine Creatine
Ardisia
Arginine malate
Anamu
Areca
adenosine triphosphate (ATP)
Algal protein
Amor seco
Arginine silicate
Atractylone
Animal protein
Beta Phenethylalamine
Blackthorn
Beta-hydroxybutyrate
Beef liver
Bovine Protein
berry
Ba Ji Tian
Borassus Palm
Borassus aethiopum
banana
Baobab
Borneol
Chia seed
Coconut
Cinnamomum
Coenzyme A
coconut oil
Codonopsis
Cynomorium
Catecholamine
Chlorophytum
Chuchuhuasi
Curcumen
Coca
Chicken
cola nut
Dendrobium
Deer Root
Deer Velvet
Dragonhead
Dextrates
D-Ribose
Dextrose
Erodium cicutarium
Egg
Elk antler
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
Egg protein
glucose
Ketone Salts
Milk Protein
peanut
Wheat
Other health conditions supported by Creatine phosphate
Athletic and Exercise AidsDepression
Energy (lack of)
Fatigue
Memory and Brain Function
Strokes
Wasting