Evidence supporting the use of: GMS-ribose
For the health condition: Energy (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
D-ribose (sometimes referred to as ribose or GMS-ribose, with GMS standing for glycosylated monosaccharide), is a naturally occurring pentose sugar that plays a crucial role in the synthesis of adenosine triphosphate (ATP), the primary energy carrier in cells. Scientific studies have explored D-ribose supplementation for its potential to support energy production, particularly in conditions characterized by impaired cellular energy metabolism.
Several small clinical trials and pilot studies have investigated D-ribose in patients with chronic fatigue syndrome (CFS), fibromyalgia, and certain cardiac conditions. For instance, a 2006 pilot study (Teitelbaum et al.) found that D-ribose supplementation improved subjective measures of energy, sleep, and well-being in patients with CFS and fibromyalgia. Other research has shown that D-ribose may help accelerate ATP replenishment in heart and skeletal muscle following ischemia or intense exercise, though these findings are largely limited to animal models or small human trials.
Despite these promising results, the overall body of evidence remains limited by small sample sizes, lack of large-scale randomized controlled trials, and reliance on subjective reporting. There is a plausible biochemical rationale for D-ribose supplementation to support energy production, but more robust clinical evidence is needed to confirm its efficacy and safety for general use in treating fatigue or low energy.
In summary, while D-ribose has a scientific basis and some preliminary clinical support for its use in supporting energy, current evidence is moderate at best (3/5), and further research is warranted.
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Acetyl L-carnitine
Acetyl-L-Tyrosine
adenosine 5-triphosphate disodium (ATP)
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Agastache
Akebia
Algae
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Alpha D-ribofuranose
Alpha polylactate
alpha-ketoglutarate (AKG)
alpinia galangal
amino acids
Amor seco
anamu
animal protein
antler
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arginine creatine
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Arginine silicate
ashwagandha
aspartic acid
atractylone
ba ji tian
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baobab
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Beef liver
berry
beta phenethylalamine
beta-alanine
beta-hydroxybutyrate
biotin
black ginger
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blackthorn
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borassus palm
borneol
bovine protein
bасора
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Codonopsis
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coffee fruit
cola nut
commiphora
cordyceps
creatine monohydrate
curcumen
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dragonhead
ecdysterone
egg
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eleuthero
elk antler
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eurycomanone
folate
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gamma-butyrobetaine
garden cress
ginseng
glucose
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greens blend (proprietary)
guarana
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guayusa
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jiaogulan
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suma
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