Evidence supporting the use of: Higenamine
For the health condition: Energy (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Higenamine is a plant-derived alkaloid found in several traditional Chinese medicinal herbs, such as Nandina domestica and Aconitum species. Recent scientific interest has centered on its potential stimulant-like and cardiovascular effects, as higenamine acts as a beta-adrenergic receptor agonist. This mechanism is similar to other stimulants that may increase energy or alertness. Several small studies and in vitro experiments suggest that higenamine can increase heart rate and may promote lipolysis, which theoretically could enhance exercise performance and perceived energy. However, most of these studies are limited in size, scope, or are preclinical. Human trials directly measuring higenamine's effect on "energy" or fatigue are scarce, and those that exist typically evaluate related endpoints such as exercise capacity or metabolic rate rather than subjective energy levels.
While there is some mechanistic support and preliminary research indicating that higenamine may have stimulant-like properties, the overall quality and quantity of evidence is low. There is not enough robust clinical data to confidently support its use for general energy enhancement in healthy individuals. Regulatory agencies, including WADA, have banned higenamine for use in sport due to its potential performance-enhancing and cardiovascular effects, further highlighting its stimulant-like action. In summary, scientific support exists but is weak to moderate, and more rigorous clinical trials are needed.
Other ingredients used for Energy (lack of)
1,3,7-Trimethylpurine-2,6-dione7-Keto-DHEA
Acai berry
Acetyl L-carnitine
Acetyl-L-Tyrosine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Agastache
Akebia
Algae
Algal protein
Almond fruit
Alpha D-ribofuranose
Alpha polylactate
alpha-ketoglutarate (AKG)
alpinia galangal
amino acids
Amor seco
anamu
animal protein
antler
Aralia
Ardisia
Areca
arginine creatine
Arginine malate
Arginine silicate
ashwagandha
aspartic acid
atractylone
ba ji tian
banana
baobab
bee pollen
Beef liver
berry
beta phenethylalamine
beta-alanine
beta-hydroxybutyrate
biotin
black ginger
black pepper
blackthorn
Borassus aethiopum
borassus palm
borneol
bovine protein
bасора
caffeine
capsaicinoids
catecholamine
chia seed
Chlorophytum
chuchuhuasi
Cinnamomum
cistanche
coca
coconut
coconut milk
coconut oil
Codonopsis
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
cola nut
commiphora
cordyceps
creatine monohydrate
curcumen
Cynomorium
D-Ribose
deer root
deer velvet
Dendrobium
dextrates
dextrose
dragonhead
ecdysterone
egg
Egg protein
electrolytes blend (proprietary)
eleuthero
elk antler
ephedrine
Erodium cicutarium
Ethyl-Alpha-Guanido-Methyl-Ethanoate
Eurycoma Longifolia
eurycomanone
folate
fungus
gamma-butyrobetaine
garden cress
ginseng
glucose
GMS-ribose
greens blend (proprietary)
guarana
Guaranine
guayusa
Herb Robert
Higenamine
Ilex
jiaogulan
jungli-bean
ketone salts
ketosterones
kola nut
L-alanyl-L-glutamine
l-carnitine
L-glutamine
L-glycine
L-leucine
l-tyrosine
lemongrass
lipids
maca
macaenes
macamides
magnesium
malic acid
maral root
medium chain triglycerides (MCT)
Methylliberine
Microbial enzymes (proprietary)
Milk
Milk Protein
Ming Dang Shen
Mushroom
Nettle
Orchis latifolia
ornithine L-aspartic acid
Oroxylum indicum
Osha
oxaloacetic acid
pantothenic acid (vitamin B5)
paraxanthine
peanut
Petiveria
Phytoecdysteroid
Plankton
pollen
Polygonatum
protein
Pseudostellaria
pyrroloquinoline disodium salt
pyrroloquinoline quinone
Rhodiola
ribose
robusta coffee
rosemary
Rubia yunnanensis
Rubiaceae
Safed musli
sage
Sarivan
shiitake mushroom
Sichuan Lovage
Sida cordifolia
siler root
Southern Tsangshu
Sphaeranthus indicus
spirulina
succinic acid
Sulbutiamine
suma
sweet flag
Synephrine
Tea
Teacrine
Terminalia
Theacrine
Theobromine
Thylakoid
Tongkat ali
trace minerals
Trichilia catigua
Trichopus zeylanicus
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
Wheat
wheat germ
Whey protein
Wulinshen
Yerba mate
Yuzu
Zedoary
Zinc
Zingiberene
Other health conditions supported by Higenamine
Athletic and Exercise AidsCardiovascular Disease
Chest Pain
Energy (lack of)
Exercise
Fat Metabolism (poor)
Heart (weakness)