Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Microbial enzymes, such as amylase, protease, lipase, and cellulase, are primarily used as digestive aids to help break down carbohydrates, proteins, fats, and fiber in the gastrointestinal tract. There is some scientific rationale to suggest that improved digestion and nutrient absorption—facilitated by supplemental enzymes—could indirectly support energy levels, particularly in individuals with digestive insufficiency (e.g., exocrine pancreatic insufficiency or certain malabsorptive disorders). Some small clinical studies and case reports have shown that people with enzyme deficiencies who take microbial enzyme supplements experience improvements in fatigue and general well-being, likely due to better absorption of macronutrients and micronutrients essential for energy metabolism. However, for otherwise healthy individuals or those with general “lack of energy” not caused by a specific medical condition affecting digestion, the evidence is quite limited. Most clinical trials on enzyme supplementation focus on digestive symptoms rather than directly measuring changes in energy or fatigue. Therefore, while there is a plausible mechanism and some indirect evidence for benefit in specific populations, robust scientific validation for the use of microbial enzymes to treat general low energy is lacking. The evidence quality is low, and more research is needed to substantiate claims that microbial enzymes directly improve energy levels in the general population.

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Integrative Therapeutics Lipase Concentrate