Evidence supporting the use of: Oxaloacetic acid
For the health condition: Energy (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Oxaloacetic acid (OAA) is an intermediate compound in the citric acid cycle (Krebs cycle), which is central to cellular energy production. Its supplementation has been explored as a means to support energy metabolism and combat fatigue, with the rationale that increasing OAA availability may enhance mitochondrial function and support ATP production. Several preclinical studies and a handful of small human trials have investigated OAA supplementation, particularly in the context of chronic fatigue syndrome (CFS) and age-related declines in energy. For example, a pilot study published in 2021 investigated OAA in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and reported modest improvements in self-reported fatigue scores. Animal studies have also suggested that OAA supplementation can increase lifespan and improve mitochondrial function. However, high-quality, large-scale human clinical trials are lacking, and the precise mechanism by which exogenous OAA would influence systemic energy levels in healthy individuals remains unclear. Thus, while there is emerging scientific interest and some preliminary data, the clinical evidence to justify OAA supplementation for improving energy is currently limited, and further research is needed to establish efficacy and safety in this context.
Other ingredients used for Energy (lack of)
7-Keto-DHEAAcai berry
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Alpha D-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
aspartic acid
beta-alanine
biotin
black pepper
bасора
caffeine
capsaicinoids
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
eleuthero
folate
fructose
ginseng
greens blend (proprietary)
guarana
guayusa
L-alanyl-L-glutamine
l-carnitine
L-glutamine
L-glycine
L-leucine
l-tyrosine
maca
magnesium
malic acid
maltodextrin
medium chain triglycerides (MCT)
Microbial enzymes (proprietary)
Milk
Acetyl-L-Tyrosine
Nettle
pantothenic acid (vitamin B5)
pollen
protein
pyrroloquinoline disodium salt
Rhodiola
rosemary
sage
shiitake mushroom
black ginger
Sphaeranthus indicus
spirulina
succinic acid
Tongkat ali
Almond fruit
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
Whey protein
Zinc
suma
jiaogulan
alpinia galangal
commiphora
bee pollen
lemongrass
siler root
cistanche
sweet flag
electrolytes blend (proprietary)
trace minerals
Yerba mate
wheat germ
Algae
1,3,7-Trimethylpurine-2,6-dione
Aralia
Akebia
Alpha polylactate
antler
Agastache
arginine creatine
Ardisia
Arginine malate
anamu
Areca
Adenosine triphosphate (ATP)
Algal protein
Amor seco
Arginine silicate
atractylone
animal protein
beta phenethylalamine
blackthorn
beta-hydroxybutyrate
Beef liver
bovine protein
berry
ba ji tian
borassus palm
Borassus aethiopum
banana
baobab
borneol
chia seed
coconut
Cinnamomum
Coenzyme A
coconut oil
Codonopsis
Cynomorium
catecholamine
Chlorophytum
chuchuhuasi
curcumen
coca
chicken
cola nut
Dendrobium
deer root
deer velvet
dragonhead
dextrates
D-Ribose
dextrose
eurycomanone
Erodium cicutarium
egg
elk antler
Eurycoma Longifolia
Ethyl-Alpha-Guanido-Methyl-Ethanoate
ecdysterone
ephedrine
Egg protein
fungus
gamma-butyrobetaine
GMS-ribose
glucose
Guaranine
garden cress
Higenamine
Herb Robert
Ilex
jungli-bean
kola nut
ketone salts
ketosterones
lipids
macamides
maral root
Milk Protein
Methylliberine
Mushroom
Ming Dang Shen
macaenes
Oroxylum indicum
Orchis latifolia
oxaloacetic acid
Osha
ornithine L-aspartic acid
pyrroloquinoline quinone
paraxanthine
Phytoecdysteroid
Plankton
Pseudostellaria
Polygonatum
peanut
Petiveria
Rubiaceae
Rubia yunnanensis
ribose
robusta coffee
Sichuan Lovage
Synephrine
Sulbutiamine
Southern Tsangshu
Shellfish
Safed musli
Sarivan
Sida cordifolia
Terminalia
Theobromine
Tea
Thylakoid
Trichilia catigua
Trichopus zeylanicus
Theacrine
Teacrine
Wheat
Wulinshen
Yuzu
Zingiberene
Zedoary