Evidence supporting the use of: Pyrroloquinoline quinone disodium salt
For the health condition: Energy (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pyrroloquinoline quinone disodium salt (PQQ) has some scientific evidence supporting its use for improving energy, though the evidence is limited and not robust. PQQ is a redox cofactor and antioxidant found in various foods and is involved in mitochondrial function. Animal and cell studies indicate that PQQ may stimulate mitochondrial biogenesis (the creation of new mitochondria), which in theory could enhance cellular energy production. Some small, early-phase human studies suggest that PQQ supplementation might reduce feelings of fatigue and improve measures of energy metabolism. For example, a double-blind, placebo-controlled clinical trial in healthy adults reported that 20 mg/day of PQQ for 8 weeks led to reductions in subjective fatigue and improvement in some sleep quality parameters. However, these studies often have small sample sizes and short durations, and there is a lack of large, well-controlled trials directly assessing objective improvements in energy or fatigue in diverse populations. Overall, while there are plausible biological mechanisms and preliminary human data, the current scientific evidence supporting PQQ for energy enhancement is modest and requires further confirmation.

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Products containing Pyrroloquinoline quinone disodium salt

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