Evidence supporting the use of: Holarrhena (unspecified)
For the health condition: Enteritis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Holarrhena, particularly Holarrhena antidysenterica (also known as Kutaja or Kurchi in Ayurvedic medicine), is traditionally used in South Asian medicine to manage gastrointestinal disorders, including enteritis and dysentery. Classical Ayurvedic texts describe the use of Holarrhena bark and seeds for "Atisara" (diarrhea) and "Pravahika" (dysentery), which are conditions often overlapping with bacterial or inflammatory enteritis. The rationale for its use is based on the plant's reputed astringent, antimicrobial, and anti-inflammatory properties.

Modern scientific studies supporting these traditional uses are limited but promising. Several in vitro and animal studies have demonstrated that extracts of Holarrhena antidysenterica possess antibacterial activity against pathogens commonly implicated in enteric infections. Some rodent studies also show reduction in experimentally induced diarrhea and inflammation with Holarrhena extracts, likely due to its alkaloidal constituents such as conessine. However, robust clinical trials in humans are lacking, and most evidence remains preclinical or anecdotal.

In summary, while the use of Holarrhena for enteritis is well-rooted in traditional medicine and supported by some experimental data, there is a lack of high-quality clinical evidence to rate it higher than moderate on the evidence scale.

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