Evidence supporting the use of: Indian snakeroot
For the health condition: Epilepsy

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Indian snakeroot (Rauwolfia serpentina) has a long-standing history of use in traditional Ayurvedic medicine for a variety of neurological and psychiatric conditions, including epilepsy. Ancient Ayurvedic texts describe its use as an anticonvulsant and sedative, and it has been employed by traditional healers in India for centuries to manage seizures. The plant contains several alkaloids, most notably reserpine, which is known for its antihypertensive and antipsychotic effects. However, the evidence supporting its efficacy for epilepsy is largely anecdotal or based on traditional knowledge, rather than rigorous scientific studies.

Modern pharmacological research has focused more on reserpine’s effects on blood pressure and psychiatric disorders, with very limited clinical data available regarding its use for epilepsy. Some animal studies have indicated mild anticonvulsant activity, but these findings have not translated into robust clinical trials in humans. Furthermore, the side effect profile of reserpine—including depression, hypotension, and extrapyramidal symptoms—limits its desirability as an antiepileptic agent. As a result, while Indian snakeroot’s use in epilepsy is well documented in traditional medicine, scientific validation remains minimal, and it is not recommended in modern clinical practice for the treatment of epilepsy.

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