Onosma bracteatum, commonly known as "Gaozaban," has a long history of use in the Unani and Ayurvedic systems of medicine for various ailments, including as a nervine tonic. Its traditional use for neurological disorders, including epilepsy, is documented in classical Unani texts where it is often prescribed as part of polyherbal formulations for its supposed calming and anticonvulsant effects. However, there is little to no robust scientific evidence from clinical trials or pharmacological studies directly evaluating the efficacy of Onosma bracteatum in epilepsy. Most references to its use for epilepsy are anecdotal or based on its inclusion in traditional formulas aimed at supporting brain and nervous system health. The plant is known to contain flavonoids, phenolics, and other compounds with potential antioxidant and anti-inflammatory properties, which could theoretically contribute to neuroprotection, but this remains speculative. In summary, the use of Onosma bracteatum for epilepsy is primarily rooted in traditional practice rather than validated by scientific research, and the available evidence supporting its use for this condition is weak.