Evidence supporting the use of: Sophora (unspecified)
For the health condition: Epilepsy

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Various species of Sophora, particularly Sophora flavescens, have been used in traditional Chinese medicine (TCM) for a variety of ailments, including neurological conditions such as epilepsy. Historical TCM texts occasionally mention the use of Sophora-derived preparations for calming the mind and controlling convulsions or seizures. The traditional use is typically based on the plant’s supposed abilities to “clear heat” and “detoxify,” which are concepts rooted in TCM rather than modern biomedical frameworks. However, the documentation of Sophora’s use specifically for epilepsy is sparse and usually not the primary indication for the herb.

From a scientific perspective, there is very limited evidence to support the use of Sophora species or their alkaloids (such as matrine or oxymatrine) in the management of epilepsy. While some in vitro and animal studies have explored the neuroactive effects of Sophora alkaloids, including potential anticonvulsant actions, these findings are preliminary and not sufficient to recommend clinical use. No robust clinical trials or strong pharmacological evidence exist to validate Sophora as a treatment for epilepsy. Thus, its use is primarily justified by traditional practices rather than modern scientific validation.

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