Evidence supporting the use of: Acetyl-L-Tyrosine
For the body system: Epinephrine

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acetyl-L-Tyrosine is a modified form of the amino acid L-Tyrosine, which serves as a precursor to catecholamines, including dopamine, norepinephrine, and epinephrine. The rationale for using Acetyl-L-Tyrosine to support the "epinephrine body system" (i.e., the body's ability to synthesize and maintain levels of epinephrine/adrenaline) is based on its role in the biochemical pathway of catecholamine synthesis. Several studies have demonstrated that under conditions of acute stress, fatigue, or sleep deprivation, tyrosine supplementation can help maintain or restore cognitive function by supporting catecholamine (including epinephrine) production.

However, direct evidence specifically linking Acetyl-L-Tyrosine supplementation to increased epinephrine levels or improved "epinephrine system" function in healthy humans is limited. Most studies use L-Tyrosine, and Acetyl-L-Tyrosine is believed to be more bioavailable, but this is not firmly established in human trials. Some animal and in vitro research suggests that Acetyl-L-Tyrosine may cross the blood-brain barrier more efficiently, but robust clinical evidence is lacking. Overall, the scientific justification is plausible but not strongly validated, so it merits a moderate-low evidence score.

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