Evidence supporting the use of: Guaranine
For the body system: Epinephrine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Guaranine is a term used for the caffeine found in guarana (Paullinia cupana), a plant native to the Amazon basin. Its primary active compound, caffeine, is chemically identical to that found in coffee or tea. Caffeine is well-established as a central nervous system stimulant and exerts its effects by antagonizing adenosine receptors, which results in increased alertness and stimulation. Importantly, caffeine intake has been shown in multiple peer-reviewed studies to increase endogenous catecholamine levels, particularly epinephrine (adrenaline) and norepinephrine. This is achieved by stimulating the adrenal medulla, thereby supporting activation of the sympathetic nervous system—often referred to as the "fight or flight" response. This physiological effect is robust and forms the basis for the inclusion of caffeine-containing substances like guaranine in supplements intended to boost energy, alertness, or physical performance.

However, while the acute impact of guaranine (caffeine) on elevating epinephrine levels is well documented, the evidence for long-term benefits or safety in intentionally "supporting" the epinephrine system is less clear. Excessive or chronic use of caffeine can lead to tolerance, dependence, and negative cardiovascular or neurological effects. In summary, the use of guaranine to modulate the epinephrine system is supported by scientific evidence for short-term stimulation, but caution and moderation are advised due to potential side effects.

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Products containing Guaranine

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