Evidence supporting the use of: Tyrosine
For the body system: Epinephrine

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Tyrosine is an amino acid that serves as a precursor for the synthesis of catecholamines, including epinephrine (adrenaline), norepinephrine, and dopamine. The use of tyrosine to support the epinephrine system is justified by scientific rationale, as its metabolic pathway directly leads to the production of these neurotransmitters and hormones. Several studies have explored whether supplemental tyrosine can enhance catecholamine synthesis under conditions of acute stress, fatigue, or demanding cognitive tasks. Some evidence suggests that tyrosine supplementation may help maintain cognitive performance and mood during periods of stress—situations in which catecholamine (including epinephrine) depletion is likely. However, these effects are generally observed under acute, extreme conditions (e.g., military training, cold exposure, sleep deprivation) rather than in healthy individuals at rest.

While animal and in vitro studies demonstrate clear biochemical pathways from tyrosine to epinephrine, the translation of supplemental tyrosine into increased circulating epinephrine in humans is less well established. Clinical studies are limited in number and often feature small sample sizes. Therefore, while there is a plausible mechanism and some supporting evidence, the overall rating for scientific support is moderate (3 out of 5), reflecting the need for more robust clinical trials to confirm efficacy in broader populations.

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