Evidence supporting the use of: Yohimbines (unspecified)
For the body system: Epinephrine

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Yohimbine is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree. It has been studied for its pharmacological effects as an alpha-2 adrenergic receptor antagonist. By blocking these presynaptic receptors, yohimbine leads to increased release of norepinephrine (noradrenaline) and, to a lesser extent, epinephrine (adrenaline) in the central and peripheral nervous systems. This mechanism has been investigated for its potential to enhance sympathetic nervous system activity, which is closely tied to the "fight or flight" response mediated by catecholamines like epinephrine.

Clinically, yohimbine has been used primarily for erectile dysfunction and as a mydriatic agent, but its role in supporting or enhancing the "Epinephrine body system"—that is, the physiological pathways and effects modulated by epinephrine and related catecholamines—has some scientific basis. Studies in both animals and humans have demonstrated that yohimbine can increase plasma levels of norepinephrine and, to a lesser extent, epinephrine. This has led to its use in research settings to probe sympathetic function and to potentially boost energy, alertness, and metabolic rate.

However, the evidence is moderate (rated 3/5) because while yohimbine’s mechanism is well-characterized and its capacity to increase catecholamine levels is documented, clinical applications specifically targeting the "Epinephrine body system" are limited, with most uses being off-label or experimental. Adverse effects, such as anxiety, hypertension, and tachycardia, further limit its therapeutic application in this context.

More about Yohimbines (unspecified)
More about Epinephrine

Products containing Yohimbines (unspecified)

We currently have no products on Vitabase that contain this ingredient.