Evidence supporting the use of: Citrulline
For the health condition: Erectile Dysfunction

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrulline, particularly in the form of L-citrulline, is used to support erectile dysfunction (ED) based on emerging scientific evidence, though the strength of this evidence remains modest. L-citrulline is a non-essential amino acid that acts as a precursor to L-arginine, which in turn is a substrate for nitric oxide (NO) production. Nitric oxide is critical for vasodilation and increased blood flow, both essential for erectile function. Several small clinical trials have investigated the effects of L-citrulline supplementation on ED, with varying results. For example, a 2011 pilot study by Cormio et al. demonstrated that men with mild ED who took 1.5 grams of L-citrulline daily for one month reported improvements in erection hardness, though the effect was less pronounced than with standard pharmaceutical treatments like phosphodiesterase-5 inhibitors (e.g., sildenafil). Other studies have found similar modest benefits, particularly in men with mild to moderate ED. The mechanism is believed to be related to enhanced NO-mediated vasodilation in penile tissue. However, the overall quality of the evidence is limited by small sample sizes, short durations, and lack of large-scale randomized controlled trials. Systematic reviews and meta-analyses generally conclude that while L-citrulline appears safe and may offer some benefit for mild ED, it is not recommended as a first-line therapy. In summary, there is scientific evidence supporting citrulline’s use in ED, but it is of low to moderate quality and strength.

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