Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-arginine is a semi-essential amino acid that serves as a precursor to nitric oxide (NO), a molecule critical for vasodilation and blood flow regulation. The physiological mechanism of penile erection relies heavily on the NO pathway, which relaxes smooth muscle in the corpus cavernosum, allowing increased blood flow. Because of this, L-arginine has been investigated as a treatment for erectile dysfunction (ED). Several clinical studies and meta-analyses have assessed its efficacy. Some small randomized controlled trials have found modest improvements in erectile function among men with ED, especially when L-arginine is combined with other agents such as pycnogenol or yohimbine. However, the benefits of L-arginine alone are generally limited and inconsistent according to larger reviews and systematic studies. The evidence is considered low to moderate in quality, with some studies reporting positive effects and others showing minimal difference from placebo. The American Urological Association and European Association of Urology do not currently recommend L-arginine as a first-line therapy for ED due to insufficient robust evidence. Nevertheless, its favorable safety profile and theoretical basis for efficacy continue to make it popular as a supplement. In summary, while there is a plausible biological mechanism and some clinical evidence supporting L-arginine’s use in ED, the overall scientific validation is weak to moderate, justifying a cautious rating.

More about L-arginine
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